Proliferative lupical glomerulonephritis/focal and membrane sclerosant – Lupical nephritis: case report

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a disease of autoimmune origin, causing chronic and multisystemic inflammation. Of unknown etiology, the onset of the disease can occur due to genetic and/or environmental factors. Glomerulonephritis (GN) is usually the main cause of the use of large doses of corticosteroids (CE) and immunosuppressants, which is the condition that most requires hospitalization and the main factor related to increased mortality.  Case Description: Patient with morphological findings compatible with Lupus Proliferative Glomerulonephritis/Focal & Membranous Sclerosing – Classes III (A/C) + V, with “Full House” aspect, pattern in which IgG, IgA, IgM deposits are simultaneously detected C1q, C3. Conclusion: Systemic Lupus Erythematosus (SLE) is a multisystemic autoimmune disorder with a wide spectrum of clinical presentations. Lupus glomerulonephritis has developmental classes, divided from I to V, that follow the appearance of the kidney injury. Treatment includes corticosteroid therapy and immunosuppression.