Mucormicose associada à COVID-19: análise com base em revisão sistemática da literatura

Abstract

Introduction: The COVID-19 pandemic came the association of some opportunistic diseases such as mucormycosis, a fungal infection that affects the rhinocerebral and gastric systems. Despite the higher prevalence of cases in India, Brazil also presented case reports. The aim of this review was to provide an updated survey of the cases described. Methods: This is an integrative review of studies available in the Scielo, Pubmed and Medline databases. Results: From the studies evaluated predominant characteristics were observed in COVID-19-positive patients associated with mucormycosis: men, diabetics and hypertensive, under treatment with corticosteroids. The possible mechanism of association in these patients is due to hyperglycemia that increases the cytokine storm, already present due to Sars-Cov-2 infection, leading to endothelial destruction and organ involvement, in addition to changes in iron ion metabolism, resulting in in high mortality rate of these individuals. Conclusion: Considering the complexity of these patients, it is important to follow up and monitor them for a better understanding of the mechanisms and impacts of this association.

Key-words: Mucormycosis, COVID-19, Opportunistic diseases.