Nutritional risk and clinical outcomes in adult patients with Covid-19 hospitalized in a public hospital in DF
DOI:
https://doi.org/10.51723/hrj.v6i28.797Keywords:
COVID-19, Nutritional status, Comorbidities, Hospitalization timeAbstract
Objective: to know the nutritional profile and clinical outcomes of adults hospitalized with covid-19 in the year 2021 in a public hospital in the Federal District (DF). Materials and methods: observational, retrospective and analytical study. Data were collected through the electronic medical records of adult patients who are admitted to the emergency room of a public hospital that is a reference for the care of patients with covid-19 in the Federal District. Results: 710 adults of both sexes participated in the survey, it was found that adults with covid-19 at nutritional risk need mechanical ventilation more 87.38% (p<0.05) and died more (86.96%) (p<0.05). In addition to requiring more intensive care unit treatment (87.50%) (p<0.005). Conclusion: the present study demonstrated that patients with covid-19 who were at nutritional risk had more interventions and evolved to death. Evidencing the importance of early screening for the presence of nutritional risk in hospitalized patients with covid-19, for interventions to reduce possible unfavorable outcomes.
References
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res. 2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0. PMID:32169119; PMCID: PMC7068984.
Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate: a systematic review and meta-analysis. J Med Virol. 2020;92(6):577-583.
Chen CX, Wei ZD, Liu YJ, Cheng SZ, Guan XD. Bedside rapid placement of nasointestinal feeding tube via ultrasound-guided stylet positioning in critical COVID-19 patients. Crit Care. 2020;24(1):361.
Ge H, Wang X, Yuan X, Xiao G, Wang C, Deng T, et al. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis. 2020;39(6):1011-9.
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-481.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-1062.
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280.e8.
Zhao X, Li Y, Ge Y, Shi Y, Lv P, Zhang J, Fu G, Zhou Y, Jiang K, Lin N, Bai T, Jin R, Wu Y, Yang X, Li X. Evaluation of Nutrition Risk and Its Association With Mortality Risk in Severely and Critically Ill COVID-19 Patients. JPEN J Parenter Enteral Nutr. 2021 Jan;45(1):32-42. doi: 10.1002/jpen.1953. Epub 2020 Jul 20. PMID: 32613660; PMCID: PMC7361906.
Kucukardali Y, Yazgan Y, Solmazgul E, Sahan B, Kaplan M, Yönem A. Malnutrition screening with the Nutritional Risk Screening 2002 in internal medicine service and the intensive care unit. Anatol J Clin Invest. 2008;2(1):19-24.
Campos LF, Barreto PA, Ceniccola GD, Gonçalves RC, Matos LBN, Zambelli CMSF, et al. Revisão do parecer BRASPEN de terapia nutricional em pacientes hospitalizados com COVID-19. BRASPEN J. 2021;36(1):122-6.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res. 2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0. PMID:32169119; PMCID: PMC7068984.
Cintoni M, Rinninella E, Annetta MG, Mele MC. Nutritional management in hospital setting during SARS-CoV-2 pandemic: a real-life experience. Eur J Clin Nutr. 2020;74(5):846-847.
Lima SCVC, organizadora. Terapia nutricional para prevenção, tratamento e reabilitação de indivíduos com COVID-19. Natal: EDUFRN; 2020.
de Andrade CLT, Pereira CCA, Martins M, Lima SML, Portela MC. COVID-19 hospitalizations in Brazil’s Unified Health System (SUS). PLoS One. 2020 Dec 10;15(12):e0243126. doi: 10.1371/journal.pone.0243126. PMID: 33301479; PMCID: PMC7728222.
Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020 May;94:91-95. doi: 10.1016/j.ijid.2020.03.017. Epub 2020 Mar 12. PMID: 32173574; PMCID: PMC7194638.
Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020 May;46(5):846-848. doi: 10.1007/s00134-020-05991-x. Epub 2020 Mar 3. Erratum in: Intensive Care Med. 2020 Apr; PMID: 32125452; PMCID: PMC7080116.
Petrilli C, Jones S, Yang J, Rajagopalan H, Donnel L, Chemyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020 May 22; 369:m1966. doi: 10.1136/bmj.m1966. PMID: 32444366; PMCID: PMC7243801.
Conti P, Younes A. Coronavirus COVID-19/SARS-CoV-2 affects women less than men: clinical response to viral infection. J Biol Regul Homeost Agents. 2020 March-April;34(2):339-343. doi: 10.23812/Editorial- Conti-3. PMID: 32253888.
Moreno-Eutimio MA, López-Macías C, Pastelin-Palacios R. Bioinformatic analysis and identification of single stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes. Microbes Infect. 2020 May-Jun;22(4-5):226-9.
Avcilar H, Eken A. Could imiquimod (Aldara 5% cream) or other TLR7 agonists be used in the treatment of COVID-19? Med Hypotheses. 2020 Nov;144:110202.
Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, Shi J, Zhou M, Wu B, Yang Z, Zhang C, Yue J, Zhang Z, Renz H, Liu X, Xie J, Xie M, Zhao J. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020 Jul;146(1):110-118. doi: 10.1016/j.jaci.2020.04.006. Epub 2020 Apr 12.
CDC COVID-19 Response Team. Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) – United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020 Mar 27;69(12):343-346. doi: 10.15585/mmwr.mm6912e2. PMID: 32214079; PMCID: PMC7725513.
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Envelhecimento e saúde da pessoa idosa / Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica – Brasília : Ministério da Saúde, 2006. 192 p. il. – (Série A. Normas e Manuais Técnicos) (Cadernos de Atenção Básica, n. 19).
Peng YD, Meng K, Guan HQ, Leng L, Zhu RR, Wang BY, He MA, Cheng LX, Huang K, Zeng QT. [Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jun 24;48(6):450-455. Chinese. doi: 10.3760/cma.j.cn112148-20200220-00105. PMID: 32120458.
Bergman ZR, Tignanelli CJ, Gould R, Pendleton KM, Chipman JG, Lusczek E, Beilman G. Factors Associated with Mortality in Patients with COVID-19 Receiving Prolonged Ventilatory Support. Surg Infect (Larchmt). 2022 Dec;23(10):893-901. doi: 10.1089/sur.2022.195. Epub 2022 Nov 16. PMID: 36383156.
Fang X, Li S, Yu H, Wang P, Zhang Y, Chen Z, Li Y, Cheng L, Li W, Jia H, Ma X. Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis. Aging (Albany NY). 2020 Jul 13;12(13):12493-12503. doi: 10.18632/aging.103579. Epub 2020 Jul 13. PMID: 32658868; PMCID: PMC7377860.
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-481.
Ali AM, Kunugi H. Approaches to Nutritional Screening in Patients with Coronavirus Disease 2019 (COVID-19). Int J Environ Res Public Health. 2021 Mar 9;18(5):2772. doi: 10.3390/ijerph18052772. PMID: 33803339; PMCID: PMC7967488.
Kompaniyets, L.; Goodman, AB; Belay, B.; Freedman, DS; Sucosky, MS; Lange, SJ; Gundlapalli, AV; Boehmer, TK; Blanck, HM. Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death—United States, março–dezembro de 2020.MMWR. morb. Mortal. Semanalmente. Rep.2021,70
Rasouli N, Kern PA. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S64-73. doi: 10.1210/jc.2008-1613. PMID: 18987272; PMCID: PMC2585759.
Anderson MR, Geleris J, Anderson DR, Zucker J, Nobel YR, Freedberg D, Small-Saunders J, Rajagopalan KN, Greendyk R, Chae SR, Natarajan K, Roh D, Edwin E, Gallagher D, Podolanczuk A, Barr RG, Ferrante AW, Baldwin MR. Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection: A Retrospective Cohort Study. Ann Intern Med. 2020 Nov 17;173(10):782-790. doi: 10.7326/M20-3214. Epub 2020 Jul 29. PMID: 32726151; PMCID: PMC7397550.
Barbosa-Silva MCG, Barros AJD. Avaliação nutricional subjetiva: parte 1 – revisão de sua validade após duas décadas de uso. Arq Gastroenterol.2002;39(3):181-187.
Batista, A., Antunes, B., Faveret, G., Peres, I., Marchesi, J., Cunha, J. P., Dantas, L., Bastos, L., Carrilho L., Aguilar, S. Baião, F., Maçaira, P., Hamacher, S., & Bozza, F. (2020). Análise socioeconômica da taxa de letalidade da COVID-19 no Brasil. Nucleo de Operacoes e Inteligencia em Saude (NOIS).
Zhang P, He Z, Yu G, Peng D, Feng Y, Ling J, Wang Y, Li S, Bian Y. The modified NUTRIC score can be used for nutritional risk assessment as well as prognosis prediction in critically ill COVID-19 patients. Clin Nutr. 2021 Feb;40(2):534-541. doi: 10.1016/j.clnu.2020.05.051. Epub 2020 Jun 5. PMID: 32527576; PMCID: PMC7273137
Campos LF, Barreto PA, Ceniccola GD, Gonçalves RC, Matos LBN, Zambelli CMSF, et al. Revisão do parecer BRASPEN de terapia nutricional em pacientes hospitalizados com COVID-19. BRASPEN J. 2021;36(1):122-6.
Nicolau J, Ayala L, Sanchís P, Olivares J, Dotres K, Soler AG, Rodríguez I, Gómez LA, Masmiquel L. Influence of nutritional status on clinical outcomes among hospitalized patients with COVID-19. Clin Nutr ESPEN. 2021 Jun;43:223-229. doi: 10.1016/j.clnesp.2021.04.013. Epub 2021 Apr 29. PMID: 34024518; PMCID: PMC8084279.
Czapla M, Juárez-Vela R, Gea-Caballero V, Zieliński S, Zielińska M. The Association between Nutritional Status and In-Hospital Mortality of COVID-19 in Critically-Ill Patients in the ICU. Nutrients. 2021 Sep 22;13(10):3302. doi: 10.3390/nu13103302. PMID: 34684305; PMCID: PMC8538443.
Kondrup J, Rasmussen HH, Hamberg O, Stanga Z; Ad Hoc ESPEN Working Group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003 Jun;22(3):321-36. doi: 10.1016/s0261-5614(02)00214-5. PMID: 12765673.
Pivonello R, Auriemma RS, Pivonello C, Isidori AM, Corona G, Colao A, et al. Sex disparities in COVID-19 severity and outcome: are men weaker or women stronger? Neuroendocrinology. 2020:1–20. doi: 10.1159/000513346.
Osuna-Padilla IA, Rodríguez-Moguel NC, Aguilar-Vargas A, Rodríguez-Llamazares S. High nutritional risk using NUTRIC-Score is associated with worse outcomes in COVID-19 critically ill patients. Nutr Hosp. 2021 Jun 10;38(3):540-544. English. doi: 10.20960/nh.03440. PMID: 33765834.
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Copyright (c) 2025 Rhaylane Gomes Rodrigues, Brena Diniz de Carvalho, Maria Samara Teles de Sousa, Thaianne Marques da Costa e Silva, Bruna de Abreu Flores Toscano, Vanessa Teles Felinto Mello
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